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Caffeine is a bitter, white crystalline purine, a methylxanthine alkaloid, and is chemically related to the adenine and guanine bases of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).

Evidence of a risk during pregnancy is equivocal; some authorities recommend that pregnant women limit consumption to the equivalent of two cups of coffee per day or less.

Caffeine can produce a mild form of drug dependence – associated with withdrawal symptoms such as sleepiness, headache, and irritability – when an individual stops using caffeine after repeated daily intake.

The anti-suicidal effects of clozapine and lithium have been substantiated, but might be less specific than previously thought.

Effective pharmacological and psychological treatments of depression are important in prevention.

We searched Pub Med and the Cochrane Library using multiple terms related to suicide prevention for studies published between Jan 1, 2005, and Dec 31, 2014.

We assessed seven interventions: public and physician education, media strategies, screening, restricting access to suicide means, treatments, and internet or hotline support.The paucity of RCTs is a major limitation in the evaluation of preventive interventions.In the quest for effective suicide prevention initiatives, no single strategy clearly stands above the others.Toxic doses, over 10 grams per day for an adult, are much higher than typical doses of under 500 milligrams per day.A cup of coffee contains 80–175 mg of caffeine, depending on what "bean" (seed) is used and how it is prepared (e.g., drip, percolation, or espresso).Insufficient evidence exists to assess the possible benefits for suicide prevention of screening in primary care, in general public education and media guidelines.

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